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Rex Neal Smith |
Associate Pathologist |
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501 Warren Bldg |
Cardiovascular, Renal, |
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Department of Pathology |
Transplantation and Autopsy Pathology |
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Massachusetts General Hospital |
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Boston, MA 02421 |
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617-726-1835 |
smith.rex@mgh.harvard.edu |
Certification
American Board of Pathology, Anatomic and Clinical Pathology
American Board of Pathology, Immunopathology
Hospital Service
Clinical service includes cardiovascular, and pulmonary surgical pathology,
autopsy pathology, medical renal pathology and immunopathology including
ANCA, and flow cytometry.
Research
Research interests include transplantation pathology conducted at the
Massachusetts General Hospital and collaborative Harvard Hospitals.
Professional Societies and Memberships
American Association of Immunologists
USCAP
Renal Pathology Society
Fellow, College of American Pathology
American Society for Investigative Pathology
Society for Cardiovascular Pathology
International Society for Heart and Lung Transplantation
Transplantation Society
American Society of Transplantation
Publications
1.Rosner W, Toppel S, Smith RN. Testosterone-estradiol-binding globulin of human plasma: denaturation and protection. Biochim Biophys Acta 1974; 351 (1): 92-8.
2.Powell AE, Sloss AM, Smith RN, Makley JT, Hubay CA. Specific responsiveness of leukocytes to soluble extracts of human tumors. Int J Cancer 1975; 16 (6): 905-13.
3.Rosner W, Smith RN. Isolation and characterization of the testosterone-estradiol-binding globulin from human plasma. Use of a novel affinity column. Biochemistry 1975; 14 (22): 4813-20.
4.Smith RN, Powell AE. The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cells. J Exp Med 1977; 146 (3): 899-904.
5.Powell AE, Sloss AM, Smith RN. Leukocyte-adherence inhibition: a specific assay of cell-mediated immunity dependent on lymphokine-mediated collaboration between T lymphocytes. J Immunol 1978; 120 (6): 1957-66.
6.Powell A, Sloss AM, Smith RN, Murrell H. Antigenic specificity and cellular mechanisms in leukocyte adherence inhibition analysis of immunity to simple proteins and hapten-protein conjugates. Cancer Res 1979; 39 (2 Pt 2): 570-5.
7.Smith RN, Howard JC. Heterogeneity of the tolerant state in rats with long established skin grafts. J Immunol 1980; 125 (5): 2289-94.
8.Smith RN. Inability of tolerant males to sire tolerant progeny. Nature 1981; 292 (5825): 767-8.
9.Battisto JR, Smith RN, Beckman K, Sternlicht M, Welles WL. Susceptibility to adjuvant arthritis in DA and F344 rats. A dominant trait controlled by an autosomal gene locus linked to the major histocompatibility complex. Arthritis Rheum 1982; 25 (10): 1194-200.
10.Smith RN, Beer AE, Quebbeman JF, Ayers JWT, Haines F. Discussion on: Beer, A.E., Quebbeman, J.F., Ayers, J.W.T., and Haines, F. 1981. Major histocompatibility complex antigens, maternal, and paternal immune responses, and chronic habitual abortion in humans. Amer, J. Obst. & Gyn. 141, 987, 1982. Amer. J. Obst. & Gyn. 1982; 143: 177.
11.Smith RN, Margolias RT, Sternlicht M. The alloantibody response in the allogeneically pregnant rat. II. Primary pregnancy-induced anti-RT1Aa alloantibodies are not as cross-reactive as secondary pregnancy-induced or conventionally raised alloantibodies. J Immunol 1982; 129 (2): 777-82.
12.Smith RN, Sternlicht M. The alloantibody response in the allogeneically pregnant rat. III. The location of the alloantibody-forming cells. J Immunol 1982; 129 (2): 783-6.
13.Smith RN, Sternlicht M, Butcher GW. The alloantibody response in the allogeneically pregnant rat. I. The primary and secondary responses and detection of Ir gene control. J Immunol 1982; 129 (2): 771-6.
14.Crowe WE, Battisto JR, Smith RN. The autologous mixed lymphocyte reaction is decreased in Freund's adjuvant-injected rats of arthritis-susceptible and -insusceptible strains. Arthritis Rheum 1985; 28 (5): 537-41.
15.Smith RN, Amsden A, Sudilovsky O, Coleman N, Margolies R. The alloantibody response in the allogeneically pregnant rat. IV. Analysis of the alloantibody specificities with monoclonal antibodies. J Immunol 1986; 136 (11): 4063-9.
16.Amsden A, Finke J, Coleman N, Smith RN. The alloantibody response in the allogeneically pregnant rat. V. Absence of cell-mediated immunity in high responders. J Reprod Immunol 1987; 11 (4): 261-71.
17.Amsden AF, Smith RN, Chirakalwasan N. The alloantibody response in the allogeneically pregnant rat. VI. Detection in maternal serum of specific antigen-antibody complexes. J Immunol 1988; 141 (7): 2295-302.
18.Hunt JS, Soares MJ, Lei MG, Smith RN, Wheaton D, Atherton RA, Morrison DC. Products of lipopolysaccharide-activated macrophages (tumor necrosis factor-alpha, transforming growth factor-beta) but not lipopolysaccharide modify DNA synthesis by rat trophoblast cells exhibiting the 80-kDa lipopolysaccharide-binding protein. J Immunol 1989; 143 (5): 1606-13.
19.Meagher R, Amsden A, Hunt J, Soares M, Sogor L, Smith RN. Placental CSF-like activity. Exp Hematol 1990; 18 (5): 448-51.
20.Smith RN, Amsden A, Robinson AV, Mayes JT, Schulak JA. Multiple pathways in the rejection of skin grafts. J Surg Res 1992; 52 (5): 413-5.
21.Reese TG, Weisskoff RM, Smith RN, Rosen BR, Dinsmore RE, Wedeen VJ. Imaging myocardial fiber architecture in vivo with magnetic resonance. Magn Reson Med 1995; 34 (6): 786-91.
22.Mizoguchi A, Mizoguchi E, Smith RN, Preffer FI, Bhan AK. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J Exp Med 1997; 186 (10): 1749-56.
23.Ryan ET, Butterton JR, Smith RN, Carroll PA, Crean TI, Calderwood SB. Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain. Infect Immun 1997; 65 (7): 2941-9.
24.Gilbert RJ, Reese TG, Daftary SJ, Smith RN, Weisskoff RM, Wedeen VJ. Determination of lingual myoarchitecture in whole tissue by NMR imaging of anisotropic water diffusion. Am J Physiol 1998; 275 (2 Pt 1): G363-9.
25.Friedman T, Shimizu A, Smith RN, Colvin RB, Seebach JD, Sachs DH, Iacomini J. Human CD4+ T cells mediate rejection of porcine xenografts. J Immunol 1999; 162 (9): 5256-62.
26.Friedman T, Smith RN, Colvin RB, Iacomini J. A critical role for human CD4+ T-cells in rejection of porcine islet cell xenografts. Diabetes 1999; 48 (12): 2340-8.
27.Imai M, Takigami K, Guckelberger O, Enjyoji K, Smith RN, Lin Y, Csizmadia E, Sevigny J, Rosenberg RD, Bach FH, Robson SC. Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection. Mol Med 1999; 5 (11): 743-52.
28.Lin Y, Soares MP, Sato K, Takigami K, Csizmadia E, Smith RN, Bach FH. Accommodated xenografts survive in the presence of anti-donor antibodies and complement that precipitate rejection of naive xenografts. J Immunol 1999; 163 (5): 2850-7.
29.Lin Y, Soares MP, Sato K, Csizmadia E, Robson SC, Smith RN, Bach FH. Long-term survival of hamster hearts in presensitized rats. J Immunol 2000; 164 (9): 4883-92.
30.Sevigny J, Robson SC, Waelkens E, Csizmadia E, Smith RN, Lemmens R. Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase. J Biol Chem 2000; 275 (8): 5640-7.
31.Kawai T, Sogawa H, Koulmanda M, Smith RN, O'Neil JJ, Wee SL, Boskovic S, Sykes M, Colvin RB, Sachs DH, Auchincloss H, Jr., Cosimi AB, DS CK. Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. Transplantation 2001; 72 (2): 351-4.
32.Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Sevigny J, Robson SC, Vercellotti G, Choi AM, Bach FH, Soares MP. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol 2001; 166 (6): 4185-94.
33.Smith RN, Grazette L, Houser S. Quilty lesions are specific for cardiac allografts and not cyclosporine. Circulation 2001; 104: 479-80.
34.Abdi R, Smith RN, Makhlouf L, Najafian N, Luster AD, Auchincloss H, Jr., Sayegh MH. The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection. Diabetes 2002; 51 (8): 2489-95.
35.Gunther L, Berberat PO, Haga M, Brouard S, Smith RN, Soares MP, Bach FH, Tobiasch E. Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation. Diabetes 2002; 51 (4): 994-9.
36.Makhlouf L, Kishimoto K, Smith RN, Abdi R, Koulmanda M, Winn HJ, Auchincloss H, Jr., Sayegh MH. The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade. Diabetes 2002; 51 (11): 3202-10.
37.Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 2002; 168 (10): 5278-86.
38.Smith RN, Chang Y, Houser S, Dec GW, Grazette L. Higher frequency of high-grade rejections in cardiac allograft patients after Quilty B lesions or grade 2/4 rejections. Transplantation 2002; 73 (12): 1928-32.
39.Wang N, Lee JM, Tobiasch E, Csizmadia E, Smith RN, Gollackes B, Robson SC, Bach FH, Lin Y. Induction of xenograft accommodation by modulation of elicited antibody responses. Transplantation 2002; 74 (3): 334-45.
40.Ansari MJ, Salama AD, Chitnis T, Smith RN, Yagita H, Akiba H, Yamazaki T, Azuma M, Iwai H, Khoury SJ, Auchincloss H, Jr., Sayegh MH. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 2003; 198 (1): 63-9.
41.Koulmanda M, Qipo A, Auchincloss H, Jr., Smith RN. Effects of streptozotocin on autoimmune diabetes in NOD mice. Clin Exp Immunol 2003; 134 (2): 210-6.
42.Koulmanda M, Qipo A, Chebrolu S, O'Neil J, Auchincloss H, Smith RN. The effect of low versus high dose of streptozotocin in cynomolgus monkeys (Macaca fascilularis). Am J Transplant 2003; 3 (3): 267-72.
43.Koulmanda M, Qipo A, Smith RN, Auchincloss H, Jr. Pig islet xenografts are resistant to autoimmune destruction by non-obese diabetic recipients after anti-CD4 treatment. Xenotransplantation 2003; 10 (2): 178-84.
44.Otterbein LE, Zuckerbraun BS, Haga M, Liu F, Song R, Usheva A, Stachulak C, Bodyak N, Smith RN, Csizmadia E, Tyagi S, Akamatsu Y, Flavell RJ, Billiar TR, Tzeng E, Bach FH, Choi AM, Soares MP. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med 2003; 9 (2): 183-90.
45.Tseng WY, Wedeen VJ, Reese TG, Smith RN, Halpern EF. Diffusion tensor MRI of myocardial fibers and sheets: correspondence with visible cut-face texture. J Magn Reson Imaging 2003; 17 (1): 31-42.
46.Abdi R, Means TK, Ito T, Smith RN, Najafian N, Jurewicz M, Tchipachvili V, Charo I, Auchincloss H, Jr., Sayegh MH, Luster AD. Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo. J Immunol 2004; 172 (2): 767-75.
47.Kawai T, Sogawa H, Boskovic S, Abrahamian G, Smith RN, Wee SL, Andrews D, Nadazdin O, Koyama I, Sykes M, Winn HJ, Colvin RB, Sachs DH, Cosimi AB. CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant 2004; 4 (9): 1391-8.
48.Koulmanda M, Laufer TM, Auchincloss H, Jr., Smith RN. Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response. Xenotransplantation 2004; 11 (6): 525-30.
49.Koyama I, Kawai T, Andrews D, Boskovic S, Nadazdin O, Wee SL, Sogawa H, Wu DL, Smith RN, Colvin RB, Sachs DH, Cosimi AB. Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates. Transplantation 2004; 77 (3): 460-2.
50.Nikolic B, Takeuchi Y, Leykin I, Fudaba Y, Smith RN, Sykes M. Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity. Diabetes 2004; 53 (2): 376-83.
51.Yamashita K, McDaid J, Ollinger R, Tsui TY, Berberat PO, Usheva A, Csizmadia E, Smith RN, Soares MP, Bach FH. Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts. Faseb J 2004; 18 (6): 765-7.
52.Smith RN, Brousaides N, Grazette L, Saidman S, Semigran M, Disalvo T, Madsen J, Dec GW, Perez-Atayde AR, Collins AB. C4d deposition in cardiac allografts correlates with alloantibody. J Heart Lung Transplant 2005; 24 (9): 1202-10.
53.Baggish AL, Smith RN, Palacios I, Vlahakes GJ, Yoerger DM, Picard MH, Lowry PA, Jang IK, Fifer MA. Pathological effects of alcohol septal ablation for hypertrophic obstructive cardiomyopathy. Heart 2006; 92 (12): 1773-8.
54.Boskovic S, Kawai T, Smith RN, Wee SL, Nadazdin O, Koyama I, Saidman S, Cardarelli F, Elias N, Sykes M, Strom T, Colvin RB, Sachs DH, Cosimi AB. Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates. Transplantation 2006; 82 (6): 819-25.
55.Cilmi SA, Karalius BJ, Choy W, Smith RN, Butterton JR. Fabry disease in mice protects against lethal disease caused by Shiga toxin-expressing enterohemorrhagic Escherichia coli. J Infect Dis 2006; 194 (8): 1135-40.
56.Fiorina P, Ansari MJ, Jurewicz M, Barry M, Ricchiuti V, Smith RN, Shea S, Means TK, Auchincloss H, Jr., Luster AD, Sayegh MH, Abdi R. Role of CXC chemokine receptor 3 pathway in renal ischemic injury. J Am Soc Nephrol 2006; 17 (3): 716-23.
57.Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB. Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure? Am J Transplant 2006; 6 (4): 687-96.
58.Shimizu I, Smith RN, Zhao G, Medof E, Sykes M. Decay-accelerating factor prevents acute humoral rejection induced by low levels of anti-alphaGal natural antibodies. Transplantation 2006; 81 (1): 95-100.
59.Smith RN, Kawai T, Boskovic S, Nadazdin O, Sachs DH, Cosimi AB, Colvin RB. Chronic antibody mediated rejection of renal allografts: pathological, serological and immunologic features in nonhuman primates. Am J Transplant 2006; 6 (8): 1790-8.
60.Yamashita K, Ollinger R, McDaid J, Sakahama H, Wang H, Tyagi S, Csizmadia E, Smith RN, Soares MP, Bach FH. Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs. Faseb J 2006; 20 (6): 776-8.
61.Fiorina P, Jurewicz M, Tanaka K, Behazin N, Augello A, Vergani A, von Andrian UH, Smith NR, Sayegh MH, Abdi R. Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival. Diabetes 2007; 56 (4): 912-20.
62.Izawa A, Ueno T, Jurewicz M, Ito T, Tanaka K, Takahashi M, Ikeda U, Sobolev O, Fiorina P, Smith RN, Hynes RO, Abdi R. Importance of donor- and recipient-derived selectins in cardiac allograft rejection. J Am Soc Nephrol 2007; 18 (11): 2929-36.
63.Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Depletion of CD8 Memory T Cells for Induction of Tolerance of a Previously Transplanted Kidney Allograft. Am J Transplant 2007; 7: 1055-61.
64.Lacy-Hulbert A, Ueno T, Ito T, Jurewicz M, Izawa A, Smith RN, Chase CM, Tanaka K, Fiorina P, Russell PS, Auchincloss H, Jr., Sayegh MH, Hynes RO, Abdi R. Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection. Am J Transplant 2007; 7 (5): 1080-90.
65.Smith RN, Ueno T, Ito T, Tanaka K, Shea SP, Abdi R. Chemokines and chronic heart allograft rejection. Transplantation 2007; 84 (3): 442-4.
66.Veronese F, Rotman S, Smith RN, Pelle TD, Farrell ML, Kawai T, Benedict Cosimi A, Colvin RB. Pathological and Clinical Correlates of FOXP3 Cells in Renal Allografts during Acute Rejection. Am J Transplant 2007.
67.Ansari MJ, Fiorina P, Dada S, Guleria I, Ueno T, Yuan X, Trikudanathan S, Smith RN, Freeman G, Sayegh MH. Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice. Clin Immunol 2008; 126 (2): 140-7.
68.Kunzli BM, Nuhn P, Enjyoji K, Banz Y, Smith RN, Csizmadia E, Schuppan D, Berberat PO, Friess H, Robson SC. Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice. Gastroenterology 2008; 134 (1): 292-305.
69.Smith RN, Kawai T, Boskovic S, Nadazdin O, Sachs DH, Cosimi AB, Colvin RB. Four stages and lack of stable accommodation in chronic alloantibody-mediated renal allograft rejection in Cynomolgus monkeys. Am J Transplant 2008; 8 (8): 1662-72.
70.Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation 2008; 86 (1): 54-62.
71.Solez K, Colvin RB, Racusen LC, Haas M, Sis B, Mengel M, Halloran PF, Baldwin W, Banfi G, Collins AB, Cosio f, David DSR, Drachenberg C, Einecke G, Fogo AB, Gibson IW, Glotz D, Iskandar SS, Kraus E, Lerut E, Mannon RB, Mihatsch M, Nakivell GJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Roberts I, Seron D, Smith RN, Valente M. Banff 07 classification of renal allograft pathology: Updates and future directions. American Journal of Transplantation 2008; 8: 1-8.
72.Collins AB, Smith RN, Stone JR. Classification of amyloid deposits in diagnostic cardiac specimens by immunofluorescence. Cardiovasc Pathol 2009; 18 (4): 205-16.
73.Fiorina P, Jurewicz M, Augello A, Vergani A, Dada S, La Rosa S, Selig M, Godwin J, Law K, Placidi C, Smith RN, Capella C, Rodig S, Adra CN, Atkinson M, Sayegh MH, Abdi R. Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes. J Immunol 2009; 183 (2): 993-1004.
74.Ueno T, Tanaka K, Jurewicz M, Murayama T, Guleria I, Fiorina P, Paez JC, Augello A, Vergani A, Wong M, Smith RN, Abdi R. Divergent role of donor dendritic cells in rejection versus tolerance of allografts. J Am Soc Nephrol 2009; 20 (3): 535-44.
75.Seixas E, Gozzelino R, Chora A, Ferreira A, Silva G, Larsen R, Rebelo S, Penido C, Smith RN, Coutinho A, Soares MP. Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc Natl Acad Sci U S A. 2009; 106 (37): 15837 - 15842.
76.Pakki Venkata UR, Callum M, Neuman M, Smith RN, and Trebbin W. Lymphaticourinary fistula causing chyluria and nephrotic-range proteinuria. Am J Kidney Dis. 2009; 53:A33-34.
77.Wilbur, D C, Madi, K, Colvin, R B, Duncan, L M, Faquin, W C, Ferry, J A, Frosch, M P, Houser, S L, Kradin, R L, Lauwers, G Y, Louis, D N, Mark, E J, Mino-Kenudson, M, Misdraji, J, Nielsen, G P, Pitman, M B, Rosenberg, A E, Smith, R N, Sohani, A R, Stone, J R, Tambouret, R H, Wu, C L, Young, R H, Zembowicz, A, and Klietmann, W. Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations. Arch Pathol Lab Med, 2009; 133(12): p. 1949-53.
78.Nikolic B, Onoe T, Takeuci Y, Khalpey A, Primo V, Leykin I, Smith RN, Sykes M. Distinct requirements for achievement of allotolerance versus reversal of autoimmunity via nonmyeloablative mixed chimerism induction in NOD mice. Transplantation 2010; 89: 23-32.
79.Primo VC, Marusic S, Franklin CC, Goldman WH, Achaval CG, Smith RN, Arnaout MA, Nikolic B. Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis. Clinical and Experimental Immunology, 2010; 159: 327-337.
80.Nadazdin O, Abrahomian G, Boskovic S, Smith RN, Madsen, JC, Colvin RB, Sachs DH, Cosimi AB, Kawai T, Schoenfeld, D. Stem Cell Mobilization and Collection for Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys. J. Surg. Research, in press.
81.Weiner J, Yamada K, Ishikawa Y, Moran S, Etter J, shimizu A, Smith RN, Sachs DH. Prolonged Survival of GalT-KO Swine Skin on Baboons. Xenotransplantation, in press.
Reviews
1.Rosner, W. and Smith, R.N. 1975. Isolation of testosterone estradiol binding globulin. In: Methods in Enzymology, 36:109-120. Academic Press.
2.Smith, R.N., Amsden, A., Sudilovsky, O., Coleman, N. and Margolies, R. 1986. Analysis with monoclonal antibodies of the alloantibody response in the allogeneically pregnant rat. In: Immunoregulation and Fetal Survival. Ed. T. Wegman & T. Gill. Oxford Univ. Press.
3.Bhan, A.K., Mizoguchi, E., Smith, R.N. and Mizoguchi, A. 1999. Colitis in Transgenic and Knockout Mice as a Model Human Inflammatory Bowel Disease. Immunological Reviews.169:195-207.
4.Bhan, A.K., Mizoguchi, E., Smith, R.N. and Mizoguchi, A. 1999. Experimental Models of Intestinal Inflammation: Lesson from Human IBD. Current Opinion in Gastroenterology. 15:285-290.
5.Bhan, A.K., Mizoguchi, E., Smith, R.N., Mizoguchi, A. 2000. Spontaneous chronic colitis in TCR alpha-mutant mice; an experimental model of human ulcerative colitis. International Reviews of Immunology. 19:123-138.
6.Soares, M.P., Brouard, S., Smith, R.N., Otterbein, L., Choi, A.M. and Bach, F.H. Expression of heme oxygenase-1 by endothelial cells: a protective response to injury in transplantation. 2000. Expert Opinion on Therapeutic Targets 4: 11.
7.Soares, M.P., Brouard, S., Smith, R.N., and Bach, F.H. 2001. Heme oxygenase-1, a protective gene that can protect organs from rejection. Immunological Reviews. 184:275-285.
8.Colvin, R.B. and Smith, R.N. 2005. Antibody-Mediated Organ Allograft Rejection. Nature Reviews Immunology 5:807-817.
9.Cornell, L.D., Smith, R.N. and Colvin, R.B. 2008. Kidney Transplantation: Mechanisms of Rejection and Acceptance. Annual Review of Pathology: Mechanisms of Disease. 3: 189-220.
10.Colvin, R.B.,Hirohashi, T., Farris, A.B., Minnei, F. Collins, A.B., Smith, R.N. Emerging role of B cells in chronic allograft dysfunction. Kidney International Supplement, in press.
Case reports
Case Records of the Massachusetts General Hospital. Weekly Clinicopathological Exercises.
1.Gorbach, S.L., Graeme-Cook, F., and Smith, R.N. 1994. Case 25-1994. A 58-year-old woman with bloody diarrhea after chemotherapy for carcinoma of the tongue. New England Journal of Medicine 330: 1811-1817.
2.Hauser, S.C. and Smith, R.N. 1995. Case 40-1995. A 71-year-old woman with right-lower quadrant pain and a cecal mass. New England Journal of Medicine 333:1764-1769.
3.Ives, D. and Smith, R.N. 1996. Case 17-1996. A 48-year-old man with the acquired immunodeficiency syndrome, abdominal pain, and bloody diarrhea. New England Journal of Medicine 334:1461-1467.
4.Sheets, E. and Smith, R.N. 1998. Case 3-1998. A 31-year-old woman with a pleural effusion, ascites, and persistent fever spikes. New England Journal of Medicine 338:248-254.
5.Ludmir, J. and Smith, R.N. 1998. Case 30-1998. A 30-year-old woman with increasing hypertension and proteinuria. New England Journal of Medicine 339:906-913.
6.DiSalvo, T.G., King, M.E. and Smith, R.N. 2000. Case 3-2000. A 66-year-old woman with diabetes, coronary disease, orthostatic hypotension and the nephrotic syndrome. New England Journal of Medicine 342:264-273.
7.Helfgott, S.M. and Smith, R.N. 2002. Case 21-2002. A 21-Year-Old Man with Arthritis during Treatment for Hyperthyroidism. New England Journal of Medicine 347:122-309.
8.Bloom, B. and Smith, R.N. 2003. Case 29-2002. A 17 year old boy with mitral regurgitation and pulmonary edema. New England Journal of Medicine 347:921-928.
9.Ronthal, M., Smith, R.N., Frosch, M. 2003. A 72-year old right-handed man was admitted to the hospital because of recurrent neurological symptoms. New England Journal of Medicine 349:170-180.
10.Medoff BD, Shepard JA, Smith, R.N., and Kratz A. 2005. Case 17-2005. A 22-year-old women with back and leg pain and respiratory failure. New England Journal of Medicine 352:2425-2434.
11.Wolf, M, Rose, H, and Smith, R.N. 2005. Case 28-2005: A 42-year-old man with weight loss, weakness, and a rash. New England Journal of Medicine 353:1148-1157.